2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-151930S1
    8′-Hydroxy ABA-d2
    8′-Hydroxy ABA-d2 is the deuterium labeled 8’-Hydroxy ABA.
    8′-Hydroxy ABA-d<sub>2</sub>
  • HY-106894
    Lufironil
    Lufironil (HOE 077) is a prolyl 4-hydroxylase inhibitor. Lufironil is developed for the research of chronic liver diseases including alcoholic hepatitis and liver cirrhosis.
    Lufironil
  • HY-164949
    Ribociclib acetate
    Ribociclib acetate is a degradation product of Ribociclib (HY-15777) under acid-base hydrolysis conditions. Ribociclib acetate has been predicted to be carcinogenic.
    Ribociclib acetate
  • HY-W011956R
    6-Hydroxymelatonin (Standard)
    6-Hydroxymelatonin (Standard) is the analytical standard of 6-Hydroxymelatonin. This product is intended for research and analytical applications. 6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2.
    6-Hydroxymelatonin (Standard)
  • HY-143961S
    Givinostat impurity 5-d4
    Givinostat impurity 5-d4 is the deuterium labeled Givinostat impurity 5.
    Givinostat impurity 5-d<sub>4</sub>
  • HY-143977S
    Loxapine impurity 3-d8 iodide
    Loxapine impurity 3-d8 (iodide) is the deuterium labeled Loxapine impurity 3 iodide.
    Loxapine impurity 3-d<sub>8</sub> iodide
  • HY-131269
    Febuxostat impurity 7
    		98.18%
    Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat impurity 7
  • HY-135388
    ent-Ezetimibe
    ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
    ent-Ezetimibe
  • HY-19570A
    NSC 15830 hydrochloride
    NSC 15830 (S-(1,2-Dichlorovinyl)-L-cysteine) hydrochloride is a nephrotoxin and metabolite of trichloroethylene. NSC 15830 hydrochloride inhibits pathogen-stimulated TNF-α.
    NSC 15830 hydrochloride
  • HY-135372
    Descarbamoyl cefuroxime
    Descarbamoyl cefuroxime is a degradation product of Cefuroxime. Descarbamoyl cefuroxime is also an intermediate for the synthesis of Cephalosporin antibiotics.
    Descarbamoyl cefuroxime
  • HY-W711177
    Mono(7-carboxy-2-methyloctyl) phthalate-d4
    Mono(7-carboxy-2-methyloctyl) phthalate-d4 (MCNP-d4) is the deuterium labeled Mono(7-carboxy-2-methyloctyl) phthalate (HY-133679). Mono(7-carboxy-2-methyloctyl) phthalate (MCNP) is a metabolite of Di-decyl phthalate (DDP).
    Mono(7-carboxy-2-methyloctyl) phthalate-d<sub>4</sub>
  • HY-G0003S1
    Iloperidone metabolite Hydroxy Iloperidone-d3
    Iloperidone metabolite Hydroxy Iloperidone-d3 is the deuterium labeled Iloperidone metabolite Hydroxy Iloperidone.
    Iloperidone metabolite Hydroxy Iloperidone-d<sub>3</sub>
  • HY-121899
    1-Oxo Ibuprofen
    1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
    1-Oxo Ibuprofen
  • HY-129099AR
    N-Desmethyltamoxifen hydrochloride (Standard)
    N-Desmethyltamoxifen (hydrochloride) (Standard) is the analytical standard of N-Desmethyltamoxifen (hydrochloride). This product is intended for research and analytical applications. N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
    N-Desmethyltamoxifen hydrochloride (Standard)
  • HY-123144
    N-Hydroxymethylsorafenib
    N-Hydroxymethylsorafenib is a Sorafenib (HY-10201) metabolite, and can be used for research of metabolite of Sorafenib.
    N-Hydroxymethylsorafenib
  • HY-N0873A
    Iso-Sagittatoside A
    Iso-Sagittatoside A is the metabolite of effective Erxian Decoction (EXD, a Chinese medicine prescription for menopausal syndromes) in rat plasma.
    Iso-Sagittatoside A
  • HY-143975S
    Loxapine impurity 2-d8
    Loxapine impurity 2-d8 is the deuterium labeled Loxapine impurity 2.
    Loxapine impurity 2-d<sub>8</sub>
  • HY-143964S
    Irbesartan impurity 14-d4
    Irbesartan impurity 14-d4 is the deuterium labeled Irbesartan impurity 14. Irbesartan impurity 14-d4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Irbesartan impurity 14-d<sub>4</sub>
  • HY-131273
    Febuxostat amide impurity
    Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM
    Febuxostat amide impurity
  • HY-136346S
    Ortho-hydroxy atorvastatin lactone-d5
    Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
    Ortho-hydroxy atorvastatin lactone-d<sub>5</sub>
Cat. No. Product Name / Synonyms Application Reactivity