2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-133005
    Desacetylvinblastine
    Desacetylvinblastine (4-Desacetylvinblastine) is the major metabolite of Vinblastine (HY-13780) and a cytotoxic agent. When used alone, desacetylvinblastine has poor anti-tumor effects, but it can exert significant anti-tumor activity when in the presence of specific conjugates.
    Desacetylvinblastine
  • HY-144242S
    Voriconazole EP impurity D-d3
    Voriconazole EP impurity D-d3 is the deuterium labeled Voriconazole EP impurity D.
    Voriconazole EP impurity D-d<sub>3</sub>
  • HY-W706930
    DCBA-d10
    DCBA-d10 is the deuterium labeled DCBA (HY-136612). DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET.
    DCBA-d<sub>10</sub>
  • HY-W766709
    Desdiacetyl bisacodyl-d13
    Desdiacetyl bisacodyl-d13 is the deuterium labeled Desacetyl bisacodyl (HY-131637). Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl. Desacetyl bisacodyl induces epithelial Cl(-) secretion in rat colon and rectum. Desacetyl bisacodyl evokes several effects at the colon or rectum, including increased mucus and chloride secretion.
    Desdiacetyl bisacodyl-d<sub>13</sub>
  • HY-136498AR
    T-705RMP ammonium (Standard)
    Rilmenidine (phosphate) (Standard) is the analytical standard of Rilmenidine (phosphate). This product is intended for research and analytical applications. Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .
    T-705RMP ammonium (Standard)
  • HY-12784AS1
    Cycloguanil-d6 hydrochloride
    Cycloguanil-d6 hydrochloride is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil-d<sub>6</sub> hydrochloride
  • HY-131622
    7-Aminoclonazepam
    		Control
    7-Aminoclonazepam is a major metabolite of Clonazepam that can be for the assessment of Clonazepam use.
    7-Aminoclonazepam
  • HY-133694S
    2-Aminoflubendazole-13C6
    2-Aminoflubendazole-13C6 is the 13C6 labeled 2-Aminoflubendazole. 2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes.
    2-Aminoflubendazole-<sup>13</sup>C<sub>6</sub>
  • HY-137414
    20-Hydroxy Prostaglandin E2
    20-Hydroxy Prostaglandin E2 (20-Hydroxy-PGE2) is a metabolite of Prostaglandin E2 (HY-101952) that can be metabolized by cytochrome P450.
    20-Hydroxy Prostaglandin E2
  • HY-I0678S
    Regorafénib N-oxyde-d3(M2)
    Regorafénib N-oxyde-d3(M2) is the deuterium labeled Regorafénib N-oxyde M2. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
    Regorafénib N-oxyde-d<sub>3</sub>(M2)
  • HY-66008S2
    N-Acetyl mesalazine-13C6
    N-Acetyl mesalazine-13C6 (N-Acetyl-5-aminosalicylic acid-13C6) is a deuterated labeled N-Acetyl mesalazine (HY-66008). N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer.
    N-Acetyl mesalazine-<sup>13</sup>C<sub>6</sub>
  • HY-139391
    (±)10(11)-DiHDPA
    (±)10(11)-DiHDPA is a fatty acid diol and a metabolite of epoxidized fatty acids (EpFAs).
    (±)10(11)-DiHDPA
  • HY-143985S
    Maytansinoid DM4 impurity 5-d6
    Maytansinoid DM4 impurity 5-d6 is the deuterium labeled Maytansinoid DM4 impurity 5.
    Maytansinoid DM4 impurity 5-d<sub>6</sub>
  • HY-W703632
    2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol
    2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol is the deuterium labeled Ibuprofen alcohol (HY-131261). Ibuprofen alcohol, a nonsteroidal antiinflammatory agent (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs).
    2-(4-Isobutylphenyl)propan-3,3,3-d<sub>3</sub>-1-ol
  • HY-169044
    (±)10,11-EDT
    (±)10,11-EDT is an oxylipin and a metabolite of Adrenic acid (HY-W013215).
    (±)10,11-EDT
  • HY-116441
    4-Hydroxy-3-methoxyamphetamine hydrochloride
    4-Hydroxy-3-methoxyamphetamine hydrochloride is a metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 4-Hydroxy-3-methoxyamphetamine hydrochloride can be used for forensic analysis.
    4-Hydroxy-3-methoxyamphetamine hydrochloride
  • HY-144221S
    Tiotropium bromide EP impurity A-d6
    Tiotropium bromide EP impurity A-d6 is the deuterium labeled Tiotropium bromide EP impurity A.
    Tiotropium bromide EP impurity A-d<sub>6</sub>
  • HY-W704807
    3-Methoxytyramine-d3 hydrochloride
    3-Methoxytyramine-d3 hydrochloride (3-O-methyl Dopamine-d3 hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride (HY-103638). 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).
    3-Methoxytyramine-d<sub>3</sub> hydrochloride
  • HY-176515
    Cipepofol glucuronide
    Cipepofol glucuronide (Ciprofol Glucuronide) (M4) is a glucuronide metabolite of Ciprofol (HY-116152). Cipepofol glucuronide has no significant inhibitory activity toward P450s and UDP-glucuronosyltransferases (UGTs), and it has a lower risk of acting as a perpetrator for drug-drug interactions (DDIs). Cipepofol glucuronide can be used for anesthesia research.
    Cipepofol glucuronide
  • HY-135580A
    Raloxifene Bismethyl Ether hydrochloride
    Raloxifene Bismethyl Ether hydrochloride is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent.
    Raloxifene Bismethyl Ether hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity